3-Bromo-5-chloro-1-methylpyridin-2(1H)-one → 4-(5-chloro-1-methyl-2-oxo-3-pyridinyl)-N-[(1,l-dimethylethoxy)carbonyl]-L-phenylalanine methyl ester

온도

90 °C

A solution of 3-bromo-5-chloro-1-methyl-2-pyridone (660 mg, 2.97 mmol) and N-[(1,1-dimethylethoxy)carbonyl]-4-[(tributyl)stannyl]-L-phenylalanine methyl ester (1.7 g, 2.99 mmol) in DMF (30 mL) was deoxygenated by alternately freezing the mixture in a liquid nitrogen bath under vacuum and thawing under argon (3×). Tetrakis(triphenylphosphine)palladium (140 mg, 0.20 mmol) was added and the mixture was heated to 90° C. for 3 hr as the mixture turned dark. TLC indicated that the reaction was not complete and an additional 140 mg portion of the catalyst was added and heating continued for 4 hr. The mixture was allowed to cool and was diluted with dichloromethane and was filtered through a pad of celite. The filtrate was evaporated to dryness and the residue was dissolved in 1:1 ether:ethyl acetate (60 mL). The solution was washed with water (3×10 mL) and brine (1×10 mL) and was dried (MgSO4). The residue obtained upon concentration was chromatographed over 150 g of silica gel eluting with 7:3 ethyl acetate:hexane to give 4-(5-chloro-1-methyl-2-oxo-3-pyridinyl)-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine methyl ester (670 mg, 54%). LRMS-Electrospray: m/z 863 (2M+Na), 858 (2M+NH4), 443 (M+Na), 438 (M+NH4), 421(M+H).

1. additionan additional 140 mg portion of the catalyst was added
2. temperatureheating
3. temperatureto cool
4. filtrationwas filtered through a pad of celite
5. customThe filtrate was evaporated to dryness
6. dissolutionthe residue was dissolved in 1:1 ether
7. washThe solution was washed with water (3×10 mL) and brine (1×10 mL)
8. dry with materialwas dried (MgSO4)
9. customThe residue obtained upon concentration
10. customwas chromatographed over 150 g of silica gel eluting with 7:3 ethyl acetate

ORD 기록

ord-6ffa7d2b48c94d98b982339c51443fa3

출처 데이터셋

uspto-grants-2005_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06916933B2