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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 896086생성일: 2026년 10월 25일

2-(Methylthio)-4-(tributylstannyl)pyrimidine → [6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone

https://huagongshe.com/reaction/896086

반응식

참여 물질

역할이름HCID투입량
반응물2-(Methylthio)-4-(tributylstannyl)pyrimidineHCID 2763261—
반응물(5-Bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanoneHCID 22349594—
생성물[6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanoneHCID 2234958045%

반응 단계

[6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone is prepared in analogy to example 11 from (5-bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone and 2-methylsulfanyl-4-tributylstannanyl-pyrimidine in 45% yield:

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06919336B2
출처 데이터셋uspto-grants-2005_07
ORD IDord-1eebe55b109b43398c3ca6b4e770e79f
출처 메모uspto-grants-2005_07