Ammonium Chloride → 6-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

HRID 896211

반응식

HRID 896211 반응식
[F:1][C:2]1[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=[C:4]([N+:15]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:15][C:4]1[CH:3]=[C:2]([F:1])[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=1

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 68487872HCID 68487872, 화합물

생성물 1

HCID 684896766-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

Prepared from 4-fluoro-3-isopropyl-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 0.87 g, 3.64 mmol), ammonium chloride (1.95 g, 36.4 mmol) and iron powder (0.81 g, 14.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.77 g, 99%).

출처 및 근거

ORD 기록
ord-ef6693afce554bc98254386195eb98e6
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06919329B2

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