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HCID 69710278, 화합물 → [1-(4-hydroxy-butyl)-2-(4-methoxy-2-oxo-2H-quinolin-1-ylmethyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester

HRID 896364
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HRID 896364 반응식
C(OC(=O)NCC1C=CC2N(CCCCO)C(CN3C4C(=CC=CC=4)C(=O)N(C4CC4)C3=O)=NC=2C=1)(C)(C)C.[C:40]([O:44][C:45]([NH:47][CH2:48][C:49]1[CH:82]=[CH:81][C:52]2[N:53]([CH2:70][CH2:71][CH2:72][CH2:73][O:74]C(=O)C(C)(C)C)[C:54]([CH2:56][N:57]3[C:66]4[C:61](=[CH:62][CH:63]=[CH:64][CH:65]=4)[C:60]([O:67][CH3:68])=[CH:59][C:58]3=[O:69])=[N:55][C:51]=2[CH:50]=1)=[O:46])([CH3:43])([CH3:42])[CH3:41]>O>[C:40]([O:44][C:45](=[O:46])[NH:47][CH2:48][C:49]1[CH:82]=[CH:81][C:52]2[N:53]([CH2:70][CH2:71][CH2:72][CH2:73][OH:74])[C:54]([CH2:56][N:57]3[C:66]4[C:61](=[CH:62][CH:63]=[CH:64][CH:65]=4)[C:60]([O:67][CH3:68])=[CH:59][C:58]3=[O:69])=[N:55][C:51]=2[CH:50]=1)([CH3:43])([CH3:41])[CH3:42]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 69710278HCID 69710278, 화합물HCID 69718999[2-(3-Cyclopropyl-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-ylmethyl)-1-(4-hydroxy-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 69717811[1-(4-hydroxy-butyl)-2-(4-methoxy-2-oxo-2H-quinolin-1-ylmethyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester수율 85%

시약·촉매·용매 1

HCID 962Water
용매

실험 절차

The procedure for the preparation of [2-(3-cyclopropyl-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-ylmethyl)-1-(4-hydroxy-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester was followed starting from 2,2-dimethyl-propionic acid 4-[5-(tert-butoxycarbonylamino-methyl)-2-(4-methoxy-2-oxo-2H-quinolin-1-ylmethyl)-benzoimidazol-1-yl]-butyl ester (280 mg, 0.474 mmol). After neutralization more water was added and the resulting white precipitate collected by filtration, which was washed with water (thrice) and diethyl ether (thrice) to yield 204 mg (85%) of [1-(4-hydroxy-butyl)-2-(4-methoxy-2-oxo-2H-quinolin-1-ylmethyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester as a white solid:

후처리

  1. filtrationthe resulting white precipitate collected by filtration, which
  2. washwas washed with water (thrice) and diethyl ether (thrice)

출처 및 근거

ORD 기록
ord-6be9f20027724e6c942053140ea04459
출처 데이터셋
uspto-grants-2005_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06919331B2

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