Thionyl Chloride → (+/-)-N,N-diethyl-4-((alphaR)-3-hydroxy-alpha-((2R,5S*)-2,5-dimethyl-1-piperazinyl)benzyl)benzamide

반응식

[Si]([O:8][C:9]1[CH:10]=[C:11]([CH:27]=[CH:28][CH:29]=1)[CH:12]([C:14]1[CH:26]=[CH:25][C:17]([C:18]([N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=1)O)(C(C)(C)C)(C)C.S(Cl)(Cl)=O.[CH3:34][C@H:35]1[CH2:40][NH:39][C@H:38]([CH3:41])[CH2:37][NH:36]1.O.[F-].C([N+](CC)(CC)CC)C>>[CH2:23]([N:20]([CH2:21][CH3:22])[C:18](=[O:19])[C:17]1[CH:16]=[CH:15][C:14]([C@@H:12]([N:36]2[CH2:37][C@H:38]([CH3:41])[NH:39][CH2:40][C@H:35]2[CH3:34])[C:11]2[CH:27]=[CH:28][CH:29]=[C:9]([OH:8])[CH:10]=2)=[CH:26][CH:25]=1)[CH3:24]