Thionyl Chloride → 8-{3-[Chloro-(4-chloro-phenyl)-methyl]-phenyl}-6-isopropyl-quinoline

HRID 896682노트

반응식

HRID 896682 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH:17]=[C:18]([CH:26]([CH3:28])[CH3:27])[CH:19]=[C:20]4[C:25]=3[N:24]=[CH:23][CH:22]=[CH:21]4)[CH:11]=2)O)=[CH:4][CH:3]=1.O=S(Cl)[Cl:31]>C1C=CC=CC=1>[Cl:31][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:10]1[CH:11]=[C:12]([C:16]2[CH:17]=[C:18]([CH:26]([CH3:28])[CH3:27])[CH:19]=[C:20]3[C:25]=2[N:24]=[CH:23][CH:22]=[CH:21]3)[CH:13]=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 22350111(4-Chloro-phenyl)-[3-(6-isopropyl-quinolin-8-yl)-phenyl]-methanol

생성물 1

HCID 223501108-{3-[Chloro-(4-chloro-phenyl)-methyl]-phenyl}-6-isopropyl-quinoline

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a solution of (4-chloro-phenyl)-[3-(6-isopropyl-quinolin-8-yl)-phenyl]-methanol from Step 1 (1.0 g, 2.58 mmol) in benzene (7 mL) at 0° C. was added SOCl2 (0.375 mL, 5.2 mmol) dropwise. After 45 min. at 0-10° C., the resulting reaction mixture was filtered through silica gel and celite and then concentrated.

후처리

  1. customthe resulting reaction mixture
  2. filtrationwas filtered through silica gel and celite
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d447cc416d6a405e921c1340ad9667f7
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06919353B2

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