(S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl ester → HCID 10464546, 화합물

HRID 897165노트

반응식

HRID 897165 반응식
C([O:8][C:9](=[O:17])[C@@:10]1([C:13]([F:16])([F:15])[F:14])[O:12][CH2:11]1)C1C=CC=CC=1.[H][H]>[Pt]=O.CO>[O:12]1[CH2:11][C@@:10]1([C:13]([F:16])([F:15])[F:14])[C:9]([OH:17])=[O:8]

참가 물질

5

반응물 2

HCID 10014785(S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 10464546HCID 10464546, 화합물수율 90%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

Into a 500 ml three-necked round-bottomed flask equipped with a stirrer, (S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl ester (20.9 g, 84.9 mmol, 99 ee %) was charged, and 180 ml of methanol was added for dissolution. Platinum oxide (1.63 g) was added, and then, the reaction system was substituted by hydrogen. After stirring at room temperature for 4 hours, platinum oxide was filtered off. The solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g) was obtained (yield: 90%).

후처리

  1. customInto a 500 ml three-necked round-bottomed flask equipped with a stirrer
  2. filtrationplatinum oxide was filtered off
  3. distillationThe solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g)
  4. customwas obtained (yield: 90%)

출처 및 근거

ORD 기록
ord-ee5de33be4fd47aa995c76b52ed103ef
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06921832B2

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