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Trifluoroacetic acid → 5-(piperidin-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine

HRID 897408
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HRID 897408 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:19]3[CH:20]=[N:21][N:22]=[C:18]3[C:17]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=3)=[C:16]([C:33]3[CH:38]=[CH:37][N:36]=[C:35]([NH:39][C@H:40]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[CH3:41])[CH:34]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH:8]1[CH2:9][CH2:10][CH:11]([C:14]2[N:19]3[CH:20]=[N:21][N:22]=[C:18]3[C:17]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:31])([F:30])[F:32])[CH:24]=3)=[C:16]([C:33]3[CH:38]=[CH:37][N:36]=[C:35]([NH:39][C@H:40]([C:42]4[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=4)[CH3:41])[CH:34]=3)[N:15]=2)[CH2:12][CH2:13]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 208169055-(1-(t-butoxycarbonyl)piperidin-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine

생성물 1

HCID 208169165-(piperidin-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5-(1-(t-butoxycarbonyl)piperidin-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine (0.03 g, 0.05 mmol) and trifluoroacetic acid (1 ml) were combined in methylene chloride (5 ml) and maintained at room temperature for 24 hours. The solution was concentrated and the residue was partitioned between methylene chloride and 10% sodium carbonate. The organic layer was separated, dried over sodium sulfate, filtered and the solvent evaporated to give the product as a syrup; MS m/z (M+H)+ 544.1; C30H28F3N7 require 543.2.

후처리

  1. concentrationThe solution was concentrated
  2. customthe residue was partitioned between methylene chloride and 10% sodium carbonate
  3. customThe organic layer was separated
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-d931276ced2144f2b91df3329a6ac91f
출처 데이터셋
uspto-grants-2005_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06921762B2

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