(S)-2-Benzylpiperazine → HCID 20816900, 화합물

HRID 897416노트

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HRID 897416 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:12]2[N:13]([CH:25]=[N:26][N:27]=2)[C:14](SC)=[N:15][C:16]=1[C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1.[CH2:28]([C@H:35]1[CH2:40][NH:39][CH2:38][CH2:37][NH:36]1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>CN(C=O)C>[CH2:28]([C@@H:35]1[NH:36][CH2:37][CH2:38][N:39]([C:14]2[N:13]3[CH:25]=[N:26][N:27]=[C:12]3[C:11]([C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[CH:1]=3)=[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[N:15]=2)[CH2:40]1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

참가 물질

4

반응물 2

HCID 20760001(S)-2-BenzylpiperazineHCID 22346600HCID 22346600, 화합물

생성물 1

HCID 20816900HCID 20816900, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
100 °C

실험 절차

8-(2-naphthyl)-5-methylthio-7-(4-pyridyl)-1,2,4-triazolo[4,3-c]pyrimidine (200 mg, 0.54 mmol), K3CO3 (100 mg) and (S)-2-benzylpiperazine (170 mg, 0.97 mmol) were combined in dry DMF (ca. 4 mL) and the mixture was heated at 100° C. for 48 h. The reaction was cooled to RT, and partitioned between water and ethyl acetate. The organic layer was dried over Na2SO4 and then concentrated in vacuo. The residue was purified by flash chromatography (2-8% MeOH/NH3:CH2Cl2) to provide the product as a tan solid; MS (m/z) 498.3 (M+H)+; C31H27N7 requir. 497.59.

후처리

  1. temperatureThe reaction was cooled to RT
  2. custompartitioned between water and ethyl acetate
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by flash chromatography (2-8% MeOH/NH3:CH2Cl2)

출처 및 근거

ORD 기록
ord-6c46afab90814b499da3d651e4445c6c
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06921762B2

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