5-(1-(t-butoxycarbonyl)-1,2,3,6-tetrahydropyrid-4-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine → 5-(2(R)-(hydroxymethyl)pyrrolidin-1-yl)-7-(2-(1(S)-phenylethyl)amino-4-pyridyl)-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo[4,3-c]pyrimidine

반응식

[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]1[N:13]2[CH:14]=[N:15][N:16]=[C:12]2[C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)=[C:10]([C:27]2[CH:32]=[CH:31][N:30]=[C:29](Cl)[CH:28]=2)[N:9]=1.C(OC(N1CC=C(C2N3C=NN=C3C(C3C=CC=C(C(F)(F)F)C=3)=C(C3C=CN=C([NH:72][C@H:73]([C:75]4[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=4)[CH3:74])C=3)N=2)CC1)=O)(C)(C)C>>[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]1[N:13]2[CH:14]=[N:15][N:16]=[C:12]2[C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)=[C:10]([C:27]2[CH:32]=[CH:31][N:30]=[C:29]([NH:72][C@H:73]([C:75]3[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=3)[CH3:74])[CH:28]=2)[N:9]=1