4-Bromoaniline → 1-(4-Bromoanilino)-3-phenyl-2-propanol

HRID 897626

반응식

HRID 897626 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[O:9]1[CH2:18][CH:10]1[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:18][CH:10]([OH:9])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 78074-BromoanilineHCID 948262-(Phenylmethyl)oxirane

생성물 1

HCID 223472001-(4-Bromoanilino)-3-phenyl-2-propanol수율 70.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-bromoaniline (1.75 g, 0.0102 mol) and 2,3-epoxy-propylbenzene (1.77 g, 0.0132 mol) in methanol (40 mL) was heated at reflux for 16 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The residue was purified by flash chromatography on silica using ethyl acetate/n-heptane (1:5) as mobile phase to yield 1-(4-bromoanilino)-3-phenyl-2-propanol (2.2 g, 0.00719 mol) as a colorless oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by flash chromatography on silica

출처 및 근거

ORD 기록
ord-a1d99133df9c49e5934ae015ef333b4c
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06921763B2

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