Diethyl aluminum chloride → [2-(Dimethylamino)benzyl]-diethylaluminium

HRID 898104노트

반응식

HRID 898104 반응식
[Cl-].[CH2:2]([Al+:4][CH2:5][CH3:6])[CH3:3].[CH3:7][N:8]([CH3:17])[C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11][Li]>C1(C)C=CC=CC=1>[CH3:7][N:8]([CH3:17])[C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11][Al:4]([CH2:5][CH3:6])[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 16686102Diethyl aluminum chlorideHCID 178506851HCID 178506851, 화합물

생성물 1

HCID 18622320[2-(Dimethylamino)benzyl]-diethylaluminium수율 62%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

7.17 g (7.5 ml; 59.5 mmol) of diethylaluminium chloride were added dropwise to a suspension, cooled to −30° C., of 8.40 g (59.5 mmol) of 2-dimethylaminobenzyllithium in 150 ml of toluene in an inert nitrogen atmosphere. After slow warming to room temperature, the mixture was stirred for 15 hours in order to complete the reaction. Filtration through a D4 frit and removal of the solvent by distillation gave 8:05 g of [2-(dimethylamino)benzyl]-diethylaluminium (36.7 mmol/62%) as a colourless liquid by slow fractional distillation from the residue.

후처리

  1. customthe reaction
  2. filtrationFiltration
  3. customthrough a D4 frit and removal of the solvent
  4. distillationby distillation

출처 및 근거

ORD 기록
ord-14dd28a1d06a4e529c6798f2863cf3f4
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351678B2

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