Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 898157생성일: 2026년 10월 26일
Water → 3-(4-Bromobenzyl)-8-(3,3-diphenyl-propyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione Hydrochloride
https://huagongshe.com/reaction/898157
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,1'-(3-Bromopropylidene)bisbenzene | HCID 88333 | — |
| 반응물 | 3-(4-Bromo-benzyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione hydrochloride | HCID 69207577 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(4-Bromobenzyl)-8-(3,3-diphenyl-propyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione Hydrochloride | HCID 69207606 | 32.1% |
반응 단계
A mixture of 26.2 mg (70 μmol) of 3-(4-bromo-benzyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione hydrochloride, 21.4 mg (70 μmol) of 3,3-diphenylpropyl bromide and 29 mg (210 μmol) of potassium carbonate in 1 mL of anhydrous DMF was heated overnight at 60° C. After cooling to room temperature, 0.5 mL of water was added and the solution was extracted with DCM (2×2 mL). The crude material was purified by semi-preparative HPLC (method A) yielding 12.8 mg (32.1%) of Compound 3 as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07351713B2 |
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| 출처 데이터셋 | uspto-grants-2008_04 |
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| ORD ID | ord-a6288280573245c68b10df567eb51a5b |
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| 출처 메모 | uspto-grants-2008_04 |
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