Aniline → 2,3,4,9-tetrahydro-1H-carbazol-1-one

HRID 898308

반응식

HRID 898308 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.OC=[C:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C:11]1=[O:16]>>[C:11]1(=[O:16])[C:10]2[NH:1][C:2]3[C:7](=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:15]=2[CH2:14][CH2:13][CH2:12]1

참가 물질

3

반응물 2

HCID 6115AnilineHCID 101871Cyclohexanone, 2-(hydroxymethylene)-

생성물 1

HCID 2858652,3,4,9-tetrahydro-1H-carbazol-1-one

실험 절차

2,3,4,9-Tetrahydro-1H-carbazol-1-one was prepared from aniline (2.9 g, 31 mmol) and 2-(hydroxymethylene)cyclohexanone (3.5 g, 28 mmol) in a similar manner as described in Example 1 to give 2.5 g (49%) of a brown solid. 1H-NMR (DMSO-d6): δ 11.6 (s, 1H), 7.66 (d, 1H), 7.38 (d, 1H), 7.30 (t, 1H), 7.07 (t, 1H), 2.90 (t, 2H), 2.56 (t, 2H), 2.15 (quint, 2H); MS m/z 186 (M+1).

출처 및 근거

ORD 기록
ord-23875c76f5d1466aa25c692e00995e4e
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351733B2

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