Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → Ethyl alpha-benzylacetoacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Ethyl Acetoacetate | HCID 8868 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | Ethyl alpha-benzylacetoacetate | HCID 246929 | 74% |
반응 단계
0.1 Mol of ethyl acetoacetate, 0.1 mol of K2CO3, 0.1 mol of benzyl bromide, 0.01 mmol of PEG-400 (polyethylene glycol 400) and 100 ml of benzene were stirred at 75° C. for 7 hours. After cooling, 20 ml of saturated solution of NH4Cl was added to dissolve solid, and product was extracted with ethyl acetate. After removing the solvent, the residue was distilled under reduced pressure, and a cut fraction was collected at 116-118° C./20 Pa. Yield 74%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07351778B2 |
| 출처 데이터셋 | uspto-grants-2008_04 |
| ORD ID | ord-e2405c4aecdd42af8025950385979ec4 |
| 출처 메모 | uspto-grants-2008_04 |