Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Ethyl 2-benzyl-3-hydroxybutyrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ethyl alpha-benzylacetoacetate | HCID 246929 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Ethyl 2-benzyl-3-hydroxybutyrate | HCID 13299637 | 85% |
반응 단계
0.05 Mol of NaBH4 and 0.4 g of NaOH were added into 25 ml of water. While cooling the reactor in ice bath, a mixture of 0.07 mol of ethyl 2-benzyl-3-oxo-butyrate and 30 ml of methanol was added dropwise with stirring, and the reaction was stirred at room temperature for 5 hours. After removing the solvent, the product was extracted with ethyl acetate, and the extract was dried over anhydrous Na2SO4. Removing the solvent gave a colorless liquid of 0.06 mol. Yield 85%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07351778B2 |
| 출처 데이터셋 | uspto-grants-2008_04 |
| ORD ID | ord-3118753faaa64ad49848254dfbdd4f1f |
| 출처 메모 | uspto-grants-2008_04 |