Potassium Carbonate → 4-(2-Piperidin-1-yl-ethoxy)-phenylamine

HRID 898524노트

반응식

HRID 898524 반응식
C(=O)([O-])[O-].[K+].[K+].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10](Cl)[CH:9]=1.Cl[CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C>[N:19]1([CH2:18][CH2:17][O:14][C:11]2[CH:12]=[CH:13][C:8]([NH2:7])=[CH:9][CH:10]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 748271-(2-Chloroethyl)piperidineHCID 775784-Amino-2-chlorophenol

생성물 1

HCID 30160254-(2-Piperidin-1-yl-ethoxy)-phenylamine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

15.4 g (111.00 mmol) of potassium carbonate was added to a solution of 4.0 g (27.86 mmol) of 4-amino-2-chlorophenol and 5.1 g (27.86 mmol) of 1-(2-chloro-ethyl)-piperidine in 50 mL acetonitrile and the mixture was stirred for 48 hours at RT. The solvent was evaporated off i. vac., the residue was combined with water and the aqueous phase was exhaustively extracted with EtOAc. The combined org. extracts were washed with water, dried over magnesium sulphate, evaporated down i. vac. and the residue was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:1).

후처리

  1. customThe solvent was evaporated off i
  2. extractionthe aqueous phase was exhaustively extracted with EtOAc
  3. washextracts were washed with water
  4. dry with materialdried over magnesium sulphate
  5. customevaporated down i
  6. customand the residue was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 90:10:1)

출처 및 근거

ORD 기록
ord-9ff1f5c11f9f45ccbee9c2d8612370b8
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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