Diethylamine → 2-Chloro-N,N-diethyl-4-nitrobenzeneacetamide

HRID 898550노트

반응식

HRID 898550 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][C:12](Cl)=[O:13].[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][C:12]([N:17]([CH2:18][CH3:19])[CH2:15][CH3:16])=[O:13]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 85969188(2-Chloro-4-nitrophenyl)acetic acid chloride

생성물 1

HCID 688195332-Chloro-N,N-diethyl-4-nitrobenzeneacetamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

At 0° C. a solution of 3.20 g (13.673 mmol) (2-chloro-4-nitro-phenyl)-acetyl-chloride in 50 mL EtOAc was slowly added dropwise to a solution of 5.67 mL (54.000 mmol) diethylamine in 50 mL EtOAc, then the cooling bath was removed and the mixture was stirred for 2 h at RT . The reaction mixture was diluted with EtOAc, the org. phase was washed with water and saturated aqueous NaCl solution, dried over sodium sulphate and evaporated down i. vac.

후처리

  1. customthe cooling bath was removed
  2. additionThe reaction mixture was diluted with EtOAc
  3. washphase was washed with water and saturated aqueous NaCl solution
  4. dry with materialdried over sodium sulphate
  5. customevaporated down i

출처 및 근거

ORD 기록
ord-69b4bb77ac7b4c95bc2b5c6f4c972d39
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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