(2-Chloro-4-trifluoromethyl-phenoxy)-acetic acid → n-{3-Chloro-4-[2-(4-methyl-piperidin-1-yl)-ethyl]-phenyl}-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

HRID 898633노트

반응식

HRID 898633 반응식
[Cl:1][C:2]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=O.[Cl:17][C:18]1[CH:19]=[C:20]([NH2:33])[CH:21]=[CH:22][C:23]=1[CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([CH3:32])[CH2:28][CH2:27]1>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:33][C:6](=[O:8])[CH2:5][O:4][C:3]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:2]=2[Cl:1])[CH:21]=[CH:22][C:23]=1[CH2:24][CH2:25][N:26]1[CH2:27][CH2:28][CH:29]([CH3:32])[CH2:30][CH2:31]1

참가 물질

3

반응물 2

HCID 59691547(2-Chloro-4-trifluoromethyl-phenoxy)-acetic acidHCID 596916703-Chloro-4-[2-(4-methylpiperidin-1-yl)ethyl]phenylamine

생성물 1

HCID 10074263n-{3-Chloro-4-[2-(4-methyl-piperidin-1-yl)-ethyl]-phenyl}-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

실험 절차

Prepared analogously to Example 143 starting from (2-chloro-4-trifluoromethyl-phenoxy)-acetic acid (Z2b) and 3-chloro-4-[2-(4-methyl-piperidin-1-yl )-ethyl]-phenylamine (Z46c). The reaction mixture was poured onto ice water and the aqueous phase was extracted with EtOAc. The org. phase was dried over sodium sulphate and evaporated down i. vac. The residue was purified by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 3:1→1:1).

후처리

  1. additionThe reaction mixture was poured onto ice water
  2. extractionthe aqueous phase was extracted with EtOAc
  3. dry with materialphase was dried over sodium sulphate
  4. customevaporated down i
  5. customThe residue was purified by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 3:1→1:1)

출처 및 근거

ORD 기록
ord-ef801e24dda44504afc42149b493bb10
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351719B2

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