Potassium Carbonate → HCID 59692072, 화합물

HRID 898674노트

반응식

HRID 898674 반응식
C[Si](C#CC1C=C2C(=CC=1)OC(C)(C)CC2(C)C)(C)C.C[Si]([C:25]#[C:26][C:27]1[CH:28]=[C:29]2[C:34](=[C:35]([CH:37]=[O:38])[CH:36]=1)[O:33][C:32]([CH3:40])([CH3:39])[CH2:31][C:30]2([CH3:42])[CH3:41])(C)C.C(=O)([O-])[O-].[K+].[K+]>CO>[C:26]([C:27]1[CH:28]=[C:29]2[C:34](=[C:35]([CH:37]=[O:38])[CH:36]=1)[O:33][C:32]([CH3:40])([CH3:39])[CH2:31][C:30]2([CH3:42])[CH3:41])#[CH:25]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 596920816-Trimethlsilanylethynyl-2,2,4,4-tetramethyl chroman-8-carbaldehydeHCID 69216465trimethyl-[2-(2,2,4,4-tetramethyl-3H-chromen-6-yl)ethynyl]silane

생성물 1

HCID 59692072HCID 59692072, 화합물수율 85%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Compound 43, 1.78 g, 5.4 mmol) in methanol (20 mL) was treated with potassium carbonate (0.745 g, 5.4 mmol) and the resulting reaction mixture was stirred at ambient temperature for 3 h. The reaction mixture was filtered, the filtrate was evaporated in vacuo and the residue was subjected to flash column chromatography over silica gel (230-400 mesh) using 2-5% ethyl acetate in hexane as the eluent to afford the title compound (1.1 g, 85%).

후처리

  1. customthe resulting reaction mixture
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-b987f7c7be584d95a9cc8e28a92f5996
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351737B2

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