Bromine → 4-Bromomethyl-5-propyl-6-chloro-pyrimidine
반응식
[Br:1]Br.[Cl:3][C:4]1[C:9]([CH2:10][CH2:11][CH3:12])=[C:8]([CH3:13])[N:7]=[CH:6][N:5]=1>CC(O)=O>[Br:1][CH2:13][C:8]1[C:9]([CH2:10][CH2:11][CH3:12])=[C:4]([Cl:3])[N:5]=[CH:6][N:7]=1참가 물질
4
반응 조건
- 온도
- 85 °C
실험 절차
Br2 (0.153 ml, 3 mmol) is added dropwise to a solution of 4-chloro-6-methyl-5-propyl-pyrimidine (3 mmol) heated at 85° C. in HOAc (10 ml). After the addition, the mixture is stirred at 85° C. for 1 hour. The solvent is removed in vacuo and the residue dissolved in EtOAc (15 ml), washed with Na2S2O3 solution (sat. 5 ml), followed by NaHCO3 (10 ml), and brine (10 ml). The organic phase is dried (Na2SO4) and evaporated. The resulting yellow oil is purified by flash column chromatography, which provides the title compound.
후처리
- additionAfter the addition
- customThe solvent is removed in vacuo
- dissolutionthe residue dissolved in EtOAc (15 ml)
- washwashed with Na2S2O3 solution (sat. 5 ml)
- dry with materialThe organic phase is dried (Na2SO4)
- customevaporated
- customThe resulting yellow oil is purified by flash column chromatography, which
출처 및 근거
- ORD 기록
- ord-de3ee40559ca4a96873748834613235b
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07351826B2
반응 노트
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