Water → Perindopril erbumine monohydrate

HRID 898741노트

반응식

HRID 898741 반응식
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]>CC(C)=O>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]

참가 물질

4

반응물 2

HCID 962WaterHCID 441313Perindopril Erbumine

생성물 1

HCID 9847044Perindopril erbumine monohydrate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Perindopril erbumine (10 gms) was suspended in acetone (80 ml). To this was added water (0.4 ml) and the contents heated to dissolve the solids and cooled to ambient. The resulting slurry was filtered to obtain perindopril erbumine monohydrate (9.4 gms).

후처리

  1. temperaturethe contents heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled
  4. filtrationThe resulting slurry was filtered

출처 및 근거

ORD 기록
ord-274ca6923c744e3db9f70350da48dd55
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351840B2

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