Perindopril Erbumine → Perindopril erbumine monohydrate

HRID 898743

반응식

HRID 898743 반응식
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29]>C(OCC)(=O)C>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:6]

참가 물질

3

반응물 1

HCID 441313Perindopril Erbumine

생성물 1

HCID 9847044Perindopril erbumine monohydrate수율 163.3%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Perindopril erbumine (20 gms) was suspended in ethyl acetate (300 ml). The contents were heated to dissolve the solids and cooled to 10 EC. The resulting slurry was filtered and dried in air having a relative humidity of at least 75% to give perindopril erbumine monohydrate (17 gms).

후처리

  1. temperatureThe contents were heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled to 10 EC
  4. filtrationThe resulting slurry was filtered
  5. customdried in air

출처 및 근거

ORD 기록
ord-a699c9ecef724a7c98932c97321fce17
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351840B2

연결된 노트

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