244205-60-5 → 1-Amino-2-phenylcyclopropane-1-carboxylic acid

HRID 898860노트

반응식

HRID 898860 반응식
C(OC([NH:8][C@:9]1([C:18]([OH:20])=[O:19])[CH2:11][C@H:10]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.Cl.O1CCOCC1>C(OCC)C>[NH2:8][C@@:9]1([C:18]([OH:20])=[O:19])[CH2:11][C@@H:10]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 2734148244205-60-5HCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 1338301-Amino-2-phenylcyclopropane-1-carboxylic acid수율 101.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To commercially available (1R,2S)-1-tert-butoxycarbonylamino-2-phenylcyclopropanecarboxylic acid (130 mg, 0.45 mmol) was added 4N hydrochloric acid—1,4-dioxane solution (2.0 mL, 16 v/w) and the mixture was stirred for 1 hr at room temperature. Diethyl ether (1.0 mL) was added thereto and the mixture was stirred for 5 min, after which the resulting crystals were collected by filtration. The crystals were washed with diethyl ether (1.0 mL) and dried under reduced pressure to give the title compound (81 mg, white powder, yield 84%).

후처리

  1. stirringthe mixture was stirred for 5 min
  2. filtrationafter which the resulting crystals were collected by filtration
  3. washThe crystals were washed with diethyl ether (1.0 mL)
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-afd4e59a7c8a428b82db1d71553f88a6
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351825B2

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