Tyrosol → Tert-butyl [4-(2-hydroxyethyl)phenoxy]acetate

HRID 898888

반응식

HRID 898888 반응식
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>C(#N)C>[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 10393TyrosolHCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetate

생성물 1

HCID 23119602Tert-butyl [4-(2-hydroxyethyl)phenoxy]acetate수율 92.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 4-(2-hydroxyethyl)phenol (3.8 ml, 25.834 mmol) was dissolved in acetonitrile (25 ml), potassium carbonate (7.085 g, 51.267 mmol) and tert-butyl bromoacetate (5.000 g, 25.834 mmol) was boiled under reflux for 16 hours. The solvent was evaporated under reduced pressure. The residue was dissolved in EtOAc and washed with brine and water, dried with MgSO4 and evaporated under reduced pressure to give the desired product was obtained (6.00 g, yield 92.8%).

후처리

  1. temperatureunder reflux for 16 hours
  2. customThe solvent was evaporated under reduced pressure
  3. dissolutionThe residue was dissolved in EtOAc
  4. washwashed with brine and water
  5. dry with materialdried with MgSO4
  6. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-58f39174f9d74c3780ae4c7f363807aa
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07351858B2

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