Ethanolamine → 4-{2-[(2-Hydroxyethyl)amino]ethoxy}benzonitrile

반응식

Br[CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1.[CH2:13]([CH2:15][NH2:16])[OH:14]>>[OH:14][CH2:13][CH2:15][NH:16][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1

참가 물질

반응물 2

HCID 700Ethanolamine

HCID 24522124-(2-Bromoethoxy)benzonitrile

생성물 1

HCID 690686254-{2-[(2-Hydroxyethyl)amino]ethoxy}benzonitrile

반응 조건

온도: 120 °C

실험 절차

4-(2-Bromoethoxy)benzonitrile (30 g, 0.133 mol; see step (i) above) and ethanolamine (48 mL, 0.78 mol) were mixed and refluxed, under a nitrogen atmosphere, at about 120° C. for 3 h. The reaction was quenched by addition of a sodium hydroxide solution to the mixture. The sub-title compound was extracted using DCM (2×250 mL), which was dried over anhydrous sodium sulfate and then concentrated. Yield: 13.1 g (48%).

후처리

customThe reaction was quenched by addition of a sodium hydroxide solution to the mixture
extractionThe sub-title compound was extracted
dry with materialwas dried over anhydrous sodium sulfate
concentrationconcentrated

출처 및 근거

ORD 기록: ord-00d4aad05e8c4e0792eb2acf6c3fe321
출처 데이터셋: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07354917B2

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