Methyl 3-(bromomethyl)benzoate → 3-(2'-Nitro-biphenyl-4-yloxymethyl)-benzoic acid

반응식

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N+:14]([O-:16])=[O:15])=[CH:4][CH:3]=1.C[O:18][C:19](=[O:28])[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26]Br)[CH:21]=1>>[N+:14]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([O:1][CH2:26][C:22]2[CH:21]=[C:20]([CH:25]=[CH:24][CH:23]=2)[C:19]([OH:28])=[O:18])=[CH:3][CH:4]=1)([O-:16])=[O:15]

참가 물질

반응물 2

HCID 517981Methyl 3-(bromomethyl)benzoate

HCID 155411124-Hydroxy-2'-nitrobiphenyl

생성물 1

HCID 111871663-(2'-Nitro-biphenyl-4-yloxymethyl)-benzoic acid

실험 절차

3-(2′-Nitro-biphenyl-4-yloxymethyl)-benzoic acid was prepared using general procedure A from 4-hydroxy-2′-nitrobiphenyl (available from TCI America, Portland, Oreg.) and 3-(bromomethyl)benzoic acid methyl ester (available from Lancaster Synthesis Ltd., Morcambe, Lancashire, UK). Yield: 82 mg. Mass spectrum (ES) MH+=350.

출처 및 근거

ORD 기록: ord-f16cf190826746c6995b854f7fad57b6
출처 데이터셋: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07355049B2

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