Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal → 2-[4-(4-Methoxy-5,6,7,8-tetrahydroquinolin-8-ylamino)-butyl]-isoindole-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal | HCID 77150 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 4-Methoxy-5,6,7,8-tetrahydroquinolin-8-amine | HCID 22018617 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[4-(4-Methoxy-5,6,7,8-tetrahydroquinolin-8-ylamino)-butyl]-isoindole-1,3-dione | HCID 69178790 | 54.4% |
반응 단계
Using General Procedure B: Reaction of 8-amino-4-methoxy-5,6,7,8-tetrahydroquinoline (0.297 g, 1.67 mmol) and 4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyraldehyde (0.371, 1.71 mmol) with NaBH(OAc)3 (0.493 g, 2.33 mmol) in CH2Cl2 (8 mL) for 60 minutes followed by purification of the crude material by column chromatography on silica gel (20:1 CH2Cl—2—CH3OH) provided 0.345 g (54%) of 2-[4-(4-Methoxy-5,6,7,8-tetrahydro-quinolin-8-ylamino)-butyl]-isoindole-1,3-dione as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07354934B2 |
| 출처 데이터셋 | uspto-grants-2008_04 |
| ORD ID | ord-1dbd991afb534cdaa1e32efa1e4d0f23 |
| 출처 메모 | uspto-grants-2008_04 |