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Triethylamine → 5,5-Dimethyl-3-{4-[(trifluoromethyl)sulfanyl]phenyl}imidazolidine-2,4-dione

HRID 899977
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HRID 899977 반응식
C(N(CC)CC)C.Cl.[NH2:9][C:10]([CH3:16])([CH3:15])[C:11](OC)=[O:12].[F:17][C:18]([S:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][CH:23]=1)([F:20])[F:19]>C1(C)C=CC=CC=1.C(OCC)C>[CH3:16][C:10]1([CH3:15])[NH:9][C:29](=[O:30])[N:28]([C:25]2[CH:24]=[CH:23][C:22]([S:21][C:18]([F:20])([F:17])[F:19])=[CH:27][CH:26]=2)[C:11]1=[O:12]
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참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 27333921-Isocyanato-4-[(trifluoromethyl)sulfanyl]benzeneHCID 13258034Methyl 2-aminoisobutyrate hydrochloride

생성물 1

HCID 132680685,5-Dimethyl-3-{4-[(trifluoromethyl)sulfanyl]phenyl}imidazolidine-2,4-dione수율 95.6%

시약·촉매·용매 2

HCID 1140Toluene용매
HCID 3283
Diethyl Ether
용매

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온도
20 °C

실험 절차

5.12 ml of triethylamine and 2.8 g of methyl α-aminoisobutyrate hydrochloride are added to a solution of 4 g of 4-trifluoromethylsulfanylphenyl isocyanate in 40 ml of toluene, under an inert atmosphere of argon at a temperature in the region of 20° C. The mixture thus obtained is refluxed for 24 hours and then cooled to a temperature in the region of 20° C. The reaction mixture is concentrated to dryness under reduced pressure and the residue obtained is taken up in ethyl ether and filtered. 5.3 g of 5,5-dimethyl-3-(4-trifluoromethylsulfanylphenyl)-imidazolidine-2,4-dione are thus obtained, the characteristics of which product are as follows:

후처리

  1. customThe mixture thus obtained
  2. temperatureis refluxed for 24 hours
  3. concentrationThe reaction mixture is concentrated to dryness under reduced pressure
  4. customthe residue obtained
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-7b9e4615779349b6b2b44f2541a350a5
출처 데이터셋
uspto-grants-2008_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07354933B2

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