Pyridine → 2-Cyano-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester
반응식
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8](I)=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2].[N:13]1C=CC=C[CH:14]=1>>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([C:14]#[N:13])=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2]참가 물질
3
반응 조건
- 온도
- 110 °C
실험 절차
To a solution of 1 g 2-Iodo-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester in 3 ml pyridine 640 mg CuCN were added and the mixture stirred for 3 h at 110° C. Then the pyridine was removed under reduced pressure and the residue was directly purified by chromatography on silica eluting with DCM/MeOH 97:3. Yield: 494 mg.
후처리
- customThen the pyridine was removed under reduced pressure
- customthe residue was directly purified by chromatography on silica eluting with DCM/MeOH 97:3
출처 및 근거
- ORD 기록
- ord-9a2880d9c85343aa94cb5cd7092eb253
- 출처 데이터셋
- uspto-grants-2008_04
- 특허 번호
- US07358268B2
반응 노트
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