참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | 3-(2-Bromo-4-nitrophenyl)-1,3-dihydroquinazoline-2,4-dione | HCID 22064401 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | HCID 22064383 | HCID 22064383 | 94% |
반응 단계
A suspension of 3-(2-bromo-4-nitrophenyl)-1,3-dihydroquinazoline-2,4-dione (0.18 g, 0.5 mmol) and tin (II) chloride dihydrate (0.45 g, 2.0 mmol) in ethyl acetate (5 mL) was heated at 70° C. for 4 hr. The reaction mixture was then cooled, mixed with Celite, made basic with 4N NaOH (3 mL), filtered through Celite, and concentrated in vacuo to give the desired compound (0.155 g, 94%). ES-MS (M+H)+=332, 334 (Br).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07358257B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_04 |
|---|
| ORD ID | ord-ef1a6845c6ae48888b78d7340303ec40 |
|---|
| 출처 메모 | uspto-grants-2008_04 |
|---|
