Acetyl chloride → 1-(2-Chloro-benzylidene)-piperidinium chloride

HRID 9003

반응식

[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1[CH:10]=O.C(Cl)(=O)C>>[Cl-:7].[Cl:7][C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1[CH:10]=[N+:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 3

HCID 6367Acetyl chloride

HCID 69962-Chlorobenzaldehyde

HCID 8082Piperidine

생성물 1

HCID 179587471-(2-Chloro-benzylidene)-piperidinium chloride

실험 절차

The reaction of 8.5 g (0.100 mol) piperidine and 7.0 g (0.050 mol) 2-chlorobenzaldehyde in accordance with general synthesis instructions 2 and subsequent reaction with 3.9 g (0.050 mol) acetyl chloride in accordance with general synthesis instructions 3 gave 7.1 g (corresponding to 58% of the yield calculated by theory) 1-(2-chloro-benzylidene)-piperidinium chloride.

후처리

customwith general synthesis instructions 3

출처 및 근거

ORD 기록: ord-b6f01e61c48544b0ba58cf7e12990b46
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07091220B2

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