Methanol → 3-[(Aminocarbonyl)amino]-5-(2-hydroxyphenyl)-2-thiophenecarboxamide

HRID 900423노트

반응식

HRID 900423 반응식
[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16]C)[S:7][C:6]=1[C:18]([NH2:20])=[O:19])=[O:3].B(Br)(Br)Br.CO>ClCCl>[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[OH:16])[S:7][C:6]=1[C:18]([NH2:20])=[O:19])=[O:3]

참가 물질

5

반응물 3

HCID 887MethanolHCID 25134Boron tribromideHCID 9835679HCID 9835679, 화합물

생성물 1

HCID 179309823-[(Aminocarbonyl)amino]-5-(2-hydroxyphenyl)-2-thiophenecarboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3-[(Aminocarbonyl)amino]-5-(2-methoxyphenyl)-2-thiophenecarboxamide (0.1 g), boron tribromide (2 ml of a 1M solution in dichloromethane) and dichloromethane (10 mL) were stirred at room temperature for 16 h. Methanol (5 mL) was added and after 1 h, the solvent was evaporated. 2M Hydrochloric acid (10 mL) was added and, after stirring for 1 h, the phenol was filtered off and used directly in step (b).

후처리

  1. customthe solvent was evaporated
  2. addition2M Hydrochloric acid (10 mL) was added
  3. filtrationthe phenol was filtered off

출처 및 근거

ORD 기록
ord-6631b47902cc406987bd878b64626c75
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07358376B2

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