1-(2-Chloroethyl)pyrrolidine → 3-[(Aminocarbonyl)amino]-5-{3-[2-(1-pyrrolidinyl)ethoxy]phenyl}-2-thiophenecarboxamide

HRID 900429노트

반응식

HRID 900429 반응식
[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)[S:7][C:6]=1[C:17]([NH2:19])=[O:18])=[O:3].Cl[CH2:21][CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>>[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:11]=2)[S:7][C:6]=1[C:17]([NH2:19])=[O:18])=[O:3]

참가 물질

3

반응물 2

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 99654243-[(Aminocarbonyl)amino]-5-(3-hydroxyphenyl)-2-thiophenecarboxamide

생성물 1

HCID 101562673-[(Aminocarbonyl)amino]-5-{3-[2-(1-pyrrolidinyl)ethoxy]phenyl}-2-thiophenecarboxamide

실험 절차

Prepared by the method of Example 9(b) using the product of Example 6 and N-(2-chloroethyl)pyrrolidine.

후처리

  1. customPrepared by the method of Example 9(b)

출처 및 근거

ORD 기록
ord-9a2aebb170ef4f3bbc87ea9b565fb513
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07358376B2

반응 노트

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