Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → 2-Acetylamino-5-bromo-3-cyanothiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | N-(3-cyanothiophen-2-yl)acetamide | HCID 676450 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Acetylamino-5-bromo-3-cyanothiophene | HCID 13052850 | — |
반응 단계
2-Acetylamino-3-cyanothiophene (13.5 g) was dissolved in dimethylformamide (110 ml) and cooled in an ice/water bath. N-Bromosuccinimide (15.9 g) was added portion wise over 20 minutes and then the mixture warmed to room temperature and stirred for 3 h. The mixture was concentrated to approximately half the volume and water added to precipitate the product. This was filtered off and dried at 60° C. under vacuum (18.8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07358376B2 |
| 출처 데이터셋 | uspto-grants-2008_04 |
| ORD ID | ord-f0baf2de5c144b1dbe1e459fa3ce055a |
| 출처 메모 | uspto-grants-2008_04 |