Dimethylformamide → (Aminothiocarbonyl)amino-5-phenyl-3-thiophenecarboxamide

HRID 900453노트

반응식

HRID 900453 반응식
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].C[Si]([N:20]=[C:21]=[S:22])(C)C.CN(C)C=O>CN(C)C(=O)C>[NH2:20][C:21]([NH:1][C:2]1[S:3][C:4]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8])=[S:22]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 75297IsothiocyanatotrimethylsilaneHCID 7039652-Amino-5-phenylthiophene-3-carboxamide

생성물 1

HCID 9814203(Aminothiocarbonyl)amino-5-phenyl-3-thiophenecarboxamide수율 35.3%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

A solution of 2-amino-5-phenyl-3-thiophenecarboxamide (1.09 g, 5 mmol) and trimethylsilyl isothiocyanate (0.85 ml, 6 mmol) in N,N-dimethylacetamide was stirred at 75° C. for 7 days. N,N-Dimethylformamide was added until solution. The solvent was removed and the resulting slurry was chromatographed on silica gel eluting with isohexane followed by methylene chloride and diethyl ether to give the product as a yellow solid (0.49 g, 35%).

후처리

  1. customThe solvent was removed
  2. customthe resulting slurry was chromatographed on silica gel eluting with isohexane

출처 및 근거

ORD 기록
ord-a9be78a2ef44464f81c5118eb59fb29c
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07358376B2

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