HCID 9834575, 화합물 → HCID 9833987, 화합물

HRID 900494노트

반응식

HRID 900494 반응식
C([O:8][CH2:9][CH2:10][C@H:11]([OH:17])[C:12]([CH3:16])([CH3:15])[C:13]#[N:14])C1C=CC=CC=1>[OH-].[OH-].[Pd+2].O1CCCC1>[OH:8][CH2:9][CH2:10][C@H:11]([OH:17])[C:12]([CH3:16])([CH3:15])[C:13]#[N:14]

참가 물질

4

반응물 1

HCID 9834575HCID 9834575, 화합물2회

생성물 1

HCID 9833987HCID 9833987, 화합물

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

16 g of Pearlman's catalyst (Pd(OH)2 on carbon, 20%) is added to 11.13 g (47.70 mmol) of 5-benzyloxy-2,2-dimethyl-3 (S)-hydroxy-pentane-nitrile of the title compound of Example 1c, dissolved in 110 ml of tetrahydrofuran. It is now hydrogenated for 7.5 hours at 10 bar and at room temperature. Catalyst is filtered out, and the filtrate is evaporated to the dry state in a vacuum.

후처리

  1. filtrationCatalyst is filtered out
  2. customthe filtrate is evaporated to the dry state in a vacuum

출처 및 근거

ORD 기록
ord-ba0305cad14747088b0e684d6cfff784
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07358382B2

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