1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → HCID 9833987, 화합물

HRID 900499노트

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HRID 900499 반응식
[OH2:1].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32])(C(C)(C)C)(C)C>>[OH:1][CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32]

참가 물질

3

반응물 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 235679315-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile2회

생성물 1

HCID 9833987HCID 9833987, 화합물

실험 절차

12.18 g (46.61 mmol) of tetrabutylammonium fluoride hydrate is added to a solution that consists of 3 g (11.65 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile of the title compound of Example 8b, dissolved in 40 ml of tetrahydrofaran, and it is stirred for 16 hours at room temperature. Then, it is evaporated to the dry state in a vacuum. The residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient).

후처리

  1. dissolutiondissolved in 40 ml of tetrahydrofaran, and it
  2. customThen, it is evaporated to the dry state in a vacuum
  3. customThe residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient)

출처 및 근거

ORD 기록
ord-96c160347ea340c3b0be0989136b2815
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07358382B2

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