[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide

HRID 901002

반응식

HRID 901002 반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([OH:17])=O)[N:13]=2)=[O:7])=[CH:4][CH:3]=1.[CH3:20][N:21]([CH3:31])[C:22](=[O:30])[CH2:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([N:27]3[CH2:26][CH2:25][N:24]([CH2:23][C:22](=[O:30])[N:21]([CH3:20])[CH3:31])[CH2:29][CH2:28]3)=[O:17])[N:13]=2)=[O:7])=[CH:18][CH:19]=1

참가 물질

3

반응물 2

HCID 677042[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acidHCID 2758642N,N-dimethyl-2-(piperazin-1-yl)acetamide

생성물 1

HCID 596988864-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide

실험 절차

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with piperazino-acetic acid N,N-dimethylamide to give 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide, using general procedure A. Amorphous white solid. MS 450.0 ([M+H]+)

출처 및 근거

ORD 기록
ord-c85db3b31e494a0194d2e7e138c39184
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07361672B2

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