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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 901091생성일: 2026년 10월 26일

Ethyl 5-hydroxy-1H-indole-2-carboxylate → 5-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/901091

반응식

참여 물질

역할이름HCID투입량
반응물Ethyl 5-hydroxy-1H-indole-2-carboxylateHCID 90677—
반응물1-Methyl-2-pyrrolidineethanolHCID 93363—
반응물5-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl esterHCID 69283274—
생성물5-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acidHCID 59699458—

반응 단계

According to the procedure described for the synthesis of Example 5/step 1 5-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl ester was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (commercially available) and 2-(1-methyl-pyrrolidin-2-yl)-ethanol (commercially available). The title compound was yielded in 38% as light brown foam. MS (m/e): 317.1 (MH+, 100%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07361682B2
출처 데이터셋uspto-grants-2008_04
ORD IDord-d2a1405bff534b2d9435c2d5b0cbac55
출처 메모uspto-grants-2008_04