4-Chloropyridine → [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine

참여 물질

역할	이름	HCID	투입량
반응물	4-Chloropyridine	HCID 12288	—
반응물	2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine	HCID 59699242	—
용매	Dimethylformamide	HCID 6228	—
생성물	[2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine	HCID 59699105	—

반응 조건

온도	100 °C

반응 단계

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine, the product of Example 512, was treated with 4-chloropyridine in DMF and was heated at 100° C. Aqueous workup and chromatography on silica gel afforded Example 519. (Yield: 80 mg)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07361678B2
출처 데이터셋	uspto-grants-2008_04
ORD ID	ord-f0758d4cb2664e00a09e4d55d1c9077f
출처 메모	uspto-grants-2008_04