C([N:3](CC)CC)C.Cl[C:9]([CH:11]=[CH:12][C:13]1[CH:18]=[CH:17][C:16](OC(=O)C2C=CC(F)=C(F)C=2)=[CH:15][CH:14]=1)=[O:10].[CH3:30][OH:31]>CN1CCCC1=O>[C:9]1(=[O:10])[NH:3][C:30](=[O:31])[CH:12]=[CH:11]1.[CH2:11]=[CH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=12.74 g (9.033 mmol) of polyhydroxymaleimide-polyhydroxystyrene was dissolved in 50 ml of N-methylpyrrolidone (NMP). After the solution was cooled to 0° C., 3.291 g (32.52 mmol) of triethylamine (Et3N) was added thereto. The mixture was stirred for 30 minutes. 6.995 g (21.679 mmol) of 3,4-difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester was added to the mixture and stirred at room temperature for 4 hours. The reaction solution was poured into an aqueous solution of methanol, and filtered to obtain a solid. The solid was washed with water several times and dried in vacuo, affording the desired compound 2 (yield: 60%).
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