1,3-Dibromopropane → 2H-1,4-Benzoxazine, 4-(3-bromopropyl)-3,4-dihydro-

HRID 901827노트

반응식

HRID 901827 반응식
[O:1]1[CH2:6][CH2:5][NH:4][C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]1=2.[Br:11][CH2:12][CH2:13][CH2:14]Br.C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C.C(OCC)(=O)C>[O:1]1[CH2:6][CH2:5][N:4]([CH2:14][CH2:13][CH2:12][Br:11])[C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]1=2

참가 물질

6

반응물 3

HCID 80011,3-DibromopropaneHCID 10340Sodium CarbonateHCID 5850963,4-Dihydro-2H-1,4-benzoxazine

생성물 1

HCID 114708452H-1,4-Benzoxazine, 4-(3-bromopropyl)-3,4-dihydro-

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

반응 조건

온도
70 °C

실험 절차

A mixture of 3,4-dihydro-2H-benzo[b][1,4]oxazine (3.0 g, 1 eq, 22.2 mmol), 1,3-dibromopropane (22.5 ml, 10 eq, 222 mmol) and anhydrous sodium carbonate (7.05 g, 3 eq, 66.6 mmol) in dry DMF (200 ml) was heated at 70° C. for 16 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The residue was chromatographed using ethyl acetate and hexane to yield the title compounds as liquid mass (2.6 g, 47%).

후처리

  1. washwashed with water and brine
  2. customThe residue was chromatographed

출처 및 근거

ORD 기록
ord-538ea71e18814810a68e0e9c5a8608eb
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365064B2

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