5-Fluoro-2-nitrophenol → Ethyl 2-(5-fluoro-2-nitrophenoxy)propanoate

HRID 901834

반응식

HRID 901834 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[OH:11])([O-:3])=[O:2].Br[CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.C(OCC)(=O)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[O:11][CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])([O-:3])=[O:2]

참가 물질

6

반응물 3

HCID 99375-Fluoro-2-nitrophenolHCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionate

생성물 1

HCID 19786322Ethyl 2-(5-fluoro-2-nitrophenoxy)propanoate

시약·촉매·용매 2

HCID 180Acetone용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-nitro-5-fluorophenol (1.0 g, 1 eq, 6.36 mmol) and ethyl 2-bromopropionate (0.91 ml, 1.1 eq, 6.99 mmol) in dry acetone (32 ml) was added anhydrous potassium carbonate (2.63 g, 3 eq, 19.08 mmol) and the reaction mixture was refluxed for 16 h. The reaction mixture was filtered through celite and then condensed on rotavapour. The residue was diluted with ethyl acetate and washed with water and brine to yield ethyl 2-(2-nitro-5-fluorophenoxy)propanoate as crude compound (1.6 g, yield 98%), which was used in step (ii).

후처리

  1. temperaturethe reaction mixture was refluxed for 16 h
  2. filtrationThe reaction mixture was filtered through celite
  3. customcondensed on rotavapour
  4. washwashed with water and brine

출처 및 근거

ORD 기록
ord-27d8f674a3af46f0ab0bc45109755fb1
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365064B2

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