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Sodium Carbonate → Ethyl 4-nitro-L-phenylalanine

HRID 901841
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인쇄 미리보기

반응식

HRID 901841 반응식
Cl.[CH2:2]([O:4][C:5](=[O:18])[C@H:6]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)[NH2:7])[CH3:3].C([O-])([O-])=O.[Na+].[Na+]>C(OCC)(=O)C>[CH2:2]([O:4][C:5](=[O:18])[C@H:6]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)[NH2:7])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 6453710Ethyl 4-nitro-3-phenyl-L-alaninate monohydrochloride

생성물 1

HCID 6453711Ethyl 4-nitro-L-phenylalanine수율 89.4%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

4-nitrophenylalanine ethyl ester hydrochloride (2 g, 1.0 eq, 7.28 mmol) obtained in step (i) was dissolved in ethyl acetate (150 mL). To that Na2CO3 (386 mg, 0.5 eq, 3.64 mmol) was added and was stirred for 15 min. The reaction mixture was washed with aq. NaHCO3. The organic layer was dried (Na2SO4), and condensed to obtain 4-nitrophenylalanine ethyl ester as thick oil (1.55 g, 89%).

후처리

  1. washThe reaction mixture was washed with aq. NaHCO3
  2. customThe organic layer was dried
  3. custom(Na2SO4), and condensed

출처 및 근거

ORD 기록
ord-6d9d778bacb445ec9896a92e01a018b3
출처 데이터셋
uspto-grants-2008_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07365064B2

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