Water → 4-(Methylsulfonyl)benzonitrile

HRID 901900

반응식

HRID 901900 반응식
[OH:1]OS([O-])=O.[K+].[CH3:7][S:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1.[OH2:17]>CO>[CH3:7][S:8]([C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)(=[O:1])=[O:17]

참가 물질

5

반응물 3

HCID 962Water2회HCID 5909604-(Methylthio)benzonitrileHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 5199814-(Methylsulfonyl)benzonitrile

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of oxone (18.42 g, 0.03 mol) in water (70 ml) was added dropwise to the vigorous stirred solution of 4-methylthiobenzonitrile (1.49 g, 0.01 mol) in methanol (50 ml) at 20° C. and stirring was continued for three hours. The reaction mixture was diluted with water (50 ml) and extracted with ethyl acetate. The ethyl acetate extract was washed with water, dried over anhydrous sodium sulphate and concentrated under reduced pressure to finish the title compound (1.3 g, 72.2%), mp 145-149° C. The compound was used with out any purification for the next step. 1H-NMR (CDCl3):δ 3.1 (s, 3H), 7.8-7.9 (d, 2H), 8.08-8.1 (d, 2H).

후처리

  1. extractionextracted with ethyl acetate
  2. extractionThe ethyl acetate extract
  3. washwas washed with water
  4. dry with materialdried over anhydrous sodium sulphate
  5. concentrationconcentrated under reduced pressure
  6. customThe compound was used with out any purification for the next step

출처 및 근거

ORD 기록
ord-e49c99a73935496d9b326a44e8837331
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365069B2

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