Methyl 2-[(2-nitrophenyl)amino]acetate → 2(1H)-Quinoxalinone, 3,4-dihydro-

HRID 901940

반응식

HRID 901940 반응식
C[O:2][C:3](=O)[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N+:12]([O-])=O>C(OCC)(=O)C.CO.[Pd]>[NH:12]1[C:7]2[C:6](=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:5][CH2:4][C:3]1=[O:2]

참가 물질

5

반응물 1

HCID 11252796Methyl 2-[(2-nitrophenyl)amino]acetate

생성물 1

HCID 1859492(1H)-Quinoxalinone, 3,4-dihydro-수율 99.4%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of N-(2-nitrophenyl)glycine methyl ester (740 mg, 3.6 mmol) in ethyl acetate (50 ml) and methanol (25 ml) was hydrogenated at atmospheric pressure over a catalytic amount of 10% palladium on carbon. After 1 h the mixture was filtered and reduced to afford 1,2,3,4-tetrahydroquinoxalin-2-one as a yellow solid (530 mg, 99%).

후처리

  1. filtrationAfter 1 h the mixture was filtered

출처 및 근거

ORD 기록
ord-b71da26728394ec1875e6794cb8bd16c
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365065B2

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