p-Bromobenzenesulfonyl chloride → HCID 69206070, 화합물

HRID 901960노트

반응식

HRID 901960 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:12][NH:13][CH2:14][C:15]1[S:16][CH:17]=[C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:19]=1.C(N(CC)CC)C>ClCCl.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:13]([CH2:14][C:15]2[S:16][CH:17]=[C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:19]=2)[CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 8471TriethylamineHCID 45117596Ethyl 2-(methylaminomethyl)thiazole-4-carboxylate

생성물 1

HCID 69206070HCID 69206070, 화합물수율 67%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

4-Bromobenzenesulfonyl chloride (2.1 g, 8.2 mmol) was added to a solution of ethyl 2-(methylaminomethyl)thiazole-4-carboxylate (1.5 g, 7.5 mmol) and triethylamine (2.1 ml, 1.5 g, 15 mmol) in dichloromethane (30 ml) and the mixture was stirred for 18 h. The mixture was diluted with ethyl acetate and washed with 1N potassium hydrogen sulphate, water and brine, dried and reduced. Chromatography (35% EtOAc/65% hexanes) afforded ethyl 2-(N-(4-bromobenzenesulphonyl)-N-methylaminomethyl)thiazole-4-carboxylate (2.1 g, 67%) as a white solid.

후처리

  1. washwashed with 1N potassium hydrogen sulphate, water and brine
  2. customdried

출처 및 근거

ORD 기록
ord-757e8e0983414520884302abbbbb2205
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365065B2

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