Water → Cbz-D-prolinol

HRID 901971노트

반응식

HRID 901971 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][OH:7].O.C(=O)([O-])O.[Na+].Cl[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]>C(OCC)(=O)C>[OH:7][CH2:6][C@H:2]1[CH2:3][CH2:4][CH2:5][N:1]1[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 10387Benzyl chloroformateHCID 516892Sodium BicarbonateHCID 2724541Prolinol, (R)-

생성물 1

HCID 5314177Cbz-D-prolinol

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2 g (0.0198 mol) of (2R)-pyrrolidin-2-ylmethanol was dissolved in 20 mL of ethyl acetate, 20 mL of water was added thereto, and the mixture was stirred. 3.3 g (0.30 mol) of sodium hydrogencarbonate was added to the mixture, followed by stirring of the mixture for 5 minutes. 4.24 mL (0.03 mol) of benzyl chloroformate was added dropwise to the mixture, followed by stirring for 5 hours. After the ethyl acetate layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to quantitatively obtain the title compound.

후처리

  1. stirringby stirring of the mixture for 5 minutes
  2. stirringby stirring for 5 hours
  3. dry with materialAfter the ethyl acetate layer was dried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-75db90d82a3f47dc8b976ee7874f1654
출처 데이터셋
uspto-grants-2008_04
특허 번호
US07365067B2

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