5-Chloroindole → 5-chloro-3-[(2-methoxyphenyl)-pyrrolidin-1-yl-methyl]-1H-indole

반응식

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[Cl-].[CH3:12][O:13][C:14]1[CH:25]=[CH:24][CH:23]=[CH:22][C:15]=1[CH:16]=[N+:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:16]([C:15]1[CH:22]=[CH:23][CH:24]=[CH:25][C:14]=1[O:13][CH3:12])[N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

반응물 2

HCID 871105-Chloroindole

HCID 179122531-(2-Methoxy-benzylidene)pyrrolidinium chloride

생성물 1

HCID 102688605-chloro-3-[(2-methoxyphenyl)-pyrrolidin-1-yl-methyl]-1H-indole

실험 절차

The preparation was carried out in accordance with general synthesis instructions 4 from 5-chloro-1H-indole and 1-(2-methoxy-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 24.

후처리

customhad been prepared in accordance with example 24

출처 및 근거

ORD 기록: ord-caea7a624f0243c3b2e28a344715d0ec
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07091220B2

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